Stan Wawrinka def. No. 4 Andy Murray
Andy Murray had been a popular pick to win, based on trips to the finals at Flushing Meadows two years ago and this year's Australian Open, along with a win in Montreal last month in which he beat both Rafael Nadal and Roger Federer. Instead, he makes his second straight early exit from the U.S. Open. Last year, as the No. 2 seed, he was upset in the fourth round by Marin Cilic. Wawrinka prevailed 6-7 (3), 7-6 (4), 6-3, 6-3 in Armstrong Stadium.