2011-12 Chicago Bulls (50-16)
Since 2000, the teams with the best regular season record in the four major professional leagues have gone one-and-done 17 times. Here's a look at their futility, starting with the Chicago Bulls, who were ousted in six games by the Philadelphia 76ers, completing the first year ever that the top seed in all four leagues went one-and-done in the playoffs.
A year after Chicago reached the Eastern Conference finals, the team earned home-court advantage, even though reigning MVP Derrick Rose missed 27 regular season games. With Rose back, the Bulls looked like a title threat. But with a minute left in a playoff-opening win over the 76ers, he tore his ACL on a move near the basket. With its star out for the postseason, Chicago lost in six games to Philadelphia.