49ers 30, Packers 22
In an early-season matchup between two of the NFC's best, visiting San Francisco -- known the previous season for its top-ranked defense -- outperformed the high-powered Green Bay offense led by reigning league MVP Aaron Rodgers. Niners' QB Alex Smith played mistake-free and threw two touchdown passes, connecting with seven receivers on 20-of-26 passing. Meanwhile, tailback Frank Gore rushed for 112 yards and a score on just 17 carries. Notably, 49ers' kicker David Akers matched the longest field goal in NFL history with a 63-yarder to end the first half.