Super Bowl XLII, 2008
New York 17, New England 14
When arguably the greatest play in Super Bowl history is crucial to the winning drive against an undefeated, seemingly invincible team, you've got a valid case for this one being the best ever. After New England took a 14-10 lead late in the fourth quarter, Eli Manning led the Giants on a gritty 12-play, 83-yard drive in the final minutes. It included his improbable escape from the clutches of the Patriots pass rush and 32-yard heave that David Tyree somehow caught and held to his helmet as he was tackled by Rodney Harrison. Four plays later, Plaxico Burress caught the winning TD with 35 seconds on the clock, ending New England's dream of 19-0 perfection.