Whole new offenses and defenses would have to be devised to allow each team to exploit its strengths and minimize its weaknesses. The Giants might go to a 2-1-8 defense, figuring the eight defensive backs would make the Pygmy receivers hear more "footsteps." And the Pygmy offensive linemen might take 10-yard splits, spreading from sideline to sideline to keep the Giants from bunching up.
It's possible neither team could stop the other and final scores would climb into the hundreds. Or it's possible both teams would have great difficulty scoring, or that one would totally outclass the other. Who knows? At least it would keep pro football fans interested until the next boring Super Bowl rolls around.